No significant interaction has been seen between digoxin and most ACE inhibitors. Some studies have found that serum digoxin levels rise by about 20% or more if captopril is used, but others have found no significant changes. It has been suggested that any interaction is likely to occur only in those patients who have pre-existing
A renalimpairment.
No action usually needed. In patients with renal impairment given digoxin and captopril it may be prudent to be alert for increased digoxin effects (e.g. bradycardia).
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