Acute
renal failure has developed in kidney transplant patients taking
ciclosporin with enalapril. Oliguria was seen in another patient taking
ciclosporin with
captopril. There is a possible risk of hyperkalaemia when
ACE inhibitors are given with
ciclosporin as both drugs may raise potassium levels.
The
incidence of
renal failure appears to be low, nevertheless care and good monitoring are needed if
ACE inhibitors and
ciclosporin are used concurrently. Monitor potassium levels more closely in the initial weeks of concurrent use.