ACE INHIBITORS AND CICLOSPORIN (CYCLOSPORINE)

Acute renal failure has developed in kidney transplant patients taking ciclosporin with enalapril. Oliguria was seen in another patient taking ciclosporin with captopril. There is a possible risk of hyperkalaemia when ACE inhibitors are given with ciclosporin as both drugs may raise potassium levels.
The incidence of renal failure appears to be low, nevertheless care and good monitoring are needed if ACE inhibitors and ciclosporin are used concurrently. Monitor potassium levels more closely in the initial weeks of concurrent use.
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