has been seen in kidney transplant patients given azathioprine
. Leucopenia occasionally occurs when captopril
is given with azathiopr-
is rapidly and extensively metabolised to mercaptopurine. Mercaptopurine is therefore expected to share the interactions of azathioprine
The manufacturer of captopril
recommends that it should be used with extreme caution in patients taking immunosuppressants, especially if there is renal
impairment. They advise that differential white blood cell counts should be performed before therapy, then every 2 weeks in the first 3 months of captopril
use, and periodically thereafter. Any effect seems likely to be a group interaction, and it would therefore seem prudent to consider monitoring with any ACE inhibitor.