ACE INHIBITORS AND ANTACIDS

A Fosinopril


Mylanta (probably containing aluminium/magnesium hydroxide) reduces the bioa- vailability of fosinopril by about one-third.
The manufacturers suggest separating its dosing from that of antacids by at least 2 hours.

Other ACE inhibitors


Antacids are said to reduce the bioavailability of a number of ACE inhibitors but this seems unlikely to be clinically important (except perhaps in the case of fosinopril, see above).
Several manufacturers of ACE inhibitors warn that antacids may reduce their bioavailability, but there seems to be no evidence of a clinically significant interaction in practice.
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