Three cases of Stevens-Johnson syndrome (one fatal) and two cases of hypersensitivity have been attributed to the use of captopril with allopurinol. Anaphylaxis and myocardial infarction occurred in one man taking enalapril with allopurinol. The combination of ACE inhibitors and allopurinol may increase the risk of leucopenia and serious infection.
Patients taking both drugs should be very closely monitored for any signs of hypersensitivity (e.g. skin reactions) or low white cell count (sore throat, fever etc.), especially if they have renal impairment.
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