Three cases of Stevens-Johnson
syndrome (one fatal) and two cases of hypersensitivity have been attributed to the use of
captopril with
allopurinol. Anaphylaxis and myocardial infarction occurred in one man taking enalapril with
allopurinol. The combination of
ACE inhibitors and
allopurinol may increase the risk of leucopenia and serious
infection.
Patients taking both drugs should be very closely monitored for any signs of hypersensitivity (e.g. skin reactions) or low white cell count (sore throat, fever etc.), especially if they have
renal impairment.