PHENYTOIN AND SULFINPYRAZONE

Some limited evidence indicates that phenytoin levels may be markedly increased by sulfinpyrazone. Fosphenytoin, a prodrug of phenytoin, may interact similarly.
Warn the patient to monitor for indicators of phenytoin toxicity (blurred vision, nystagmus, ataxia or drowsiness). It would seem advisable to monitor phenytoin levels.
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