LAMOTRIGINE AND PROTEASE INHIBITORS

Lopinavir/ritonavir halved lamotrigine plasma levels, whereas the protease inhibitor levels did not appear to be altered. Saquinavir/ritonavir had similar effects in another patient and therefore reduced lamotrigine levels should be anticipated with any ritonavir-boosted regimen.
Lamotrigine efficacy should be monitored in patients taking lopinavir/ritonavir, and probably any ritonavir-boosted regimen. Anticipate the need to increase the lamotrigine dose.
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