| IDOXURIDINE (IDU)
Dendrid, Herplex Liquifilm
Classifications: antiviral; Therapeutic: antiviral
Pregnancy Category: C
0.1% ophthalmic solution
Topical antiviral agent. Pyrimidine nucleoside structurally related to thymidine, a nucleic acid essential for synthesis
of viral DNA. Antiviral activity is primarily due to inhibition of viral replication.
Inhibits growth of herpes simplex types I and II, varicella-zoster, vaccinia, cytomegalovirus, and small animal viruses
Herpes simplex keratitis as single agent or conjunctively with a corticosteroid.
Cutaneous herpes simplex.
Hypersensitivity to idoxuridine, iodine or iodine-containing preparations, or any components in the formulation, pregnancy
(category C), lactation.
Route & Dosage
|Herpes Simplex Keratitis
Adult/Child: Topical 1 drop in conjunctival sac hourly during the day and q2h at night until improvement occurs, then decrease to q2h during the
day and q4h at night
- Prevent the possibility of systemic absorption by applying light finger pressure to head of lacrimal duct for 1 min when
eyedrop is instilled.
- Follow manufacturer's directions regarding storage. Decomposed idoxuridine not only has reduced antiviral activity but also
may be toxic.
- Store ophthalmic solution refrigerated at 2°8° C (36°46° F) in a tight, light-resistant container
unless otherwise directed.
Adverse Effects (≥1%)Body as a Whole:
Sensitization, systemic absorption (stomatitis, anorexia, nausea, vomiting, alopecia
hepatotoxicity). Special Senses:
Local irritation, pain, burning, lacrimation, pruritus, inflammation, or edema of eyes, lids, and surrounding face; follicular
, photophobia; corneal ulceration and swelling; delayed healing, small defects in corneal epithelium
InteractionsDrug: Boric acid
-containing solutions may cause precipitation.
Poorly absorbed from eye tissues. Distribution:
Crosses placenta. Metabolism:
Assessment & Drug Effects
- Monitor for therapeutic effectiveness. Epithelial infections usually improve within 78 d. If patient continues to
improve, therapy is generally continued ≤21 d.
- Supervise patients closely by ophthalmologist.
Patient & Family Education
- Learn proper technique for eye drop instillation.
- Do not exceed the recommended frequency and duration of therapy.
- Wear sunglasses if photosensitivity is troublesome.