Classifications: ophthalmic diagnostic agent; Therapeutic:ophthalmic diagnostic agent
Pregnancy Category: X
100 mg/mL injection
Mildly antiseptic fluorescent dye related chemically to phenolphthalein that demonstrates defects of the corneal epithelium.
Any break in the epithelial tissue allows the dye to enter the tissue. Epithelial damage will appear as a bright green area.
Used IV as a diagnostic aid in retinal angiography. Also used as an antidote for aniline dye.
Intraarterial administration; intrathecal administration; pregnancy (category X).
History of hypersensitivity, allergies, bronchial asthma.
Route & Dosage
Adult: IV 5 mL of 10% solution or 3 mL of 25% solution injected rapidly in antecubital vein
Child: IV 7.5 mg/kg injected rapidly in antecubital vein
ADMINISTER: IV Direct for Adult: 5 mL of 10% solution or 3 mL of 25% solution injected rapidly in antecubital vein. IV Direct for Child: 7.5 mg/kg injected rapidly in antecubital vein.
Adverse Effects (≥1%)CNS:
Headache, paresthesias, pyrexia, convulsions. CV:
Hypotension, transient dyspnea
, acute pulmonary
edema, basilar artery ischemia, syncope, severe shock, cardiac arrest
Nausea, vomiting, strong metallic taste following high dosage. Body as a Whole:
Hypersensitivity (urticaria, pruritus, angioneurotic edema, anaphylactic reaction
Thrombophlebitis at injection site, temporary discoloration of skin and urine.
Assessment & Drug Effects
- Have facilities for treatment of anaphylactic reaction immediately available (e.g., epinephrine 1:1000 for IV or IM use, an
antihistamine, and oxygen).
- Discontinue fluorescein immediately if S&S of sensitivity develop.
Patient & Family Education
- Note: IV administration may impart a yellowish orange discoloration to skin and to urine. Skin discoloration usually fades in 612
h; urine clears in 2436 h.