Classifications: analgesic, nonsteroidal antiinflammatory drug (nsaid); antipyretic; Therapeutic: nsaid, analgesic; antipyretic
Pregnancy Category: B first and second trimester; D third trimester
200 mg, 300 mg capsules; 600 mg tablets
Exhibits antiinflammatory, analgesic, and antipyretic properties of an NSAID. Fenoprofen competitively inhibits both cyclooxygenase
COX-1 and COX-2 enzymes by blocking arachidonate binding to prostaglandin G2 resulting in its pharmacologic effects.
Has nonsteroidal, antiinflammatory, antipyretic, antiarthritic properties that provide relief from mild to severe pain.
Antiinflammatory and analgesic effects in the symptomatic treatment of acute and chronic rheumatoid arthritis and osteoarthritis;
relief of mild to moderate pain.
Juvenile rheumatoid arthritis, acute gouty arthritis, ankylosing spondylitis; fever associated with pulmonary tuberculosis,
type A influenza, colds; neoplasms.
Hypersensitivity to fenoprofen or other NSAIDS; history of nephrotic syndrome associated with aspirin or other NSAIDs; patient in whom urticaria, severe rhinitis, bronchospasm, angioedema, nasal polyps are precipitated by aspirin or other
NSAIDs; severe renal or hepatic dysfunction; perioperative pain associated in CABG; pregnancy (category B first and second trimester,
and category D in third trimester). Safety in lactation or children is not established.
History of upper GI tract disorders; lupus; older adults; renal failure; renal impairment; hemophilia or other bleeding tendencies;
compromised cardiac function, hypertension; impaired hearing; lactation.
Route & Dosage
Adult: PO 300600 mg t.i.d. or q.i.d. (max: 3200 mg/d)
Child: PO 900 mg/m2 in divided doses, may increase over 4 wk to 1.8 g/m2
Mild to Moderate Pain
Adult: PO 200 mg q46h prn
- Give on an empty stomach 3060 min before or 2 h after meals. Give with meals, milk, or antacid (prescribed) if patient
experiences GI disturbances.
- May crush tablets or empty capsule and mix with fluid or mix with food.
- Store capsules and tablets in tightly closed containers at 15?30? C (59?86? F); avoid freezing.
Adverse Effects (≥1%)CNS: Headache, drowsiness,
, lassitude, tremor, confusion, insomnia
, nervousness, depression
. Special Senses:
Tinnitus, decreased hearing, deafness; blurred vision. GI: Indigestion, nausea, vomiting,
anorexia, constipation, diarrhea
, flatulence, abdominal pain, dry mouth; infrequent: gastritis
, peptic ulcer
, GI bleeding
, hematuria, oliguria, azotemia, anuria, allergic nephritis, papillary necrosis, nephrotoxicity (rare). Hematologic:
, hemolytic anemia, agranulocytosis, pancytopenia
(may or may not be hypersensitivity reaction) Pruritus, rash, purpura, increased sweating, urticaria. Body as a Whole: Dyspnea
Fenoprofen may prolong bleeding time; should not be given with oral anticoagulants
action and side effects
of phenytoin, sulfonylureas
, and fenoprofen may be potentiated. Herbal: Feverfew, garlic, ginger, gingko
may increase bleeding potential.
80% from GI tract. Onset:
2 h. Peak:
2 h. Duration:
46 h. Distribution:
Small amounts distributed into breast milk. Metabolism:
In liver. Elimination:
Primarily in urine; some biliary excretion. Half-Life:
Assessment & Drug Effects
- Lab tests: Baseline evaluations of Hct and Hgb, kidney and liver function.
- Baseline and periodic auditory and ophthalmic examinations are recommended in patients receiving prolonged or high-dose therapy.
- Monitor for S&S of GI bleeding.
- Note: Dosage adjustment of fenoprofen may be required when phenobarbital is added to or withdrawn from patient's drug regimen.
Patient & Family Education
- Do not drive or engage in potentially hazardous activities until response to drug is known; fenoprofen may cause dizziness
- Report immediately the onset of unexplained fever, rash, arthralgia, oliguria, edema, weight gain to physician. Possible symptoms
of nephrotic syndrome are rapidly reversible if drug is promptly withdrawn.
- Understand that alcohol and aspirin may increase risk of GI ulceration and bleeding tendencies; avoid both unless otherwise
advised by physician.
- Inform dentist or surgeon that you are taking fenoprofen because it may prolong bleeding time.