ENTACAPONE OR TOLCAPONE AND INOTROPES AND VASOPRESSORS

Entacapone potentiated the increase in heart rate and arrhythmogenic effects of isoprenaline (isoproterenol) and adrenaline (epinephrine) in a study in healthy subjects.
The manufacturers of entacapone and tolcapone suggest caution on the concur- rent use of drugs such as adrenaline (epinephrine), dobutamine, dopamine, isoprenaline (isoproterenol) and noradrenaline (norepinephrine).
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