Classifications: biologic response modifier; monoclonal antibody; immunosuppressant; Therapeutic: immunosuppressant
Pregnancy Category: C
125 mg vial
An anti-CD11a antibody that targets the antigen-1 subunit on the surface of T-leukocytes; inhibits binding of T-cells to endothelial
cells, prevents migration of T-cells out of the bloodstream into the skin, and prevents activation of T-cells. Lymphocyte
activation and movement to skin play a key role in the pathophysiology of chronic plaque psoriasis.
Prevents activation of T-cells and their migration out of the circulatory system to sites of inflammation, thus slowing processes
that result in plaque psoriasis.
Treatment of moderate to severe plaque psoriasis.
Hypersensitivity to efalizumab; hamster protein hypersensitivity; severe infection or exposure to viral infections (e.g.,
chicken pox, herpes zoster), live vaccines; children <18 y; pregnancy (category C).
History of untoward reactions to other monoclonal antibodies; lactation.
Route & Dosage
Adult: SC 0.7 mg/kg first dose, then 1 mg/kg (max: 200 mg) once weekly
- Note: A reduced initial dose is used to prevent first dose reaction including headache, fever, nausea, and vomiting.
- Reconstitute immediately before use. Inject 1.3 mL of the supplied diluent (using prefilled syringe with sterile water for
injection) slowly into vial. Swirl gently to dissolve but DO NOT SHAKE; dissolves in <5 min. Should be clear to pale yellow
and free of particulates.
- Replace needle on syringe used for reconstitution with a new needle. Insert needle into vial keeping needle below the level
of the liquid; withdraw the required dose.
- Inject SC into thigh, abdomen, buttocks, or upper arm. Rotate sites.
- If reconstituted vial is not used immediately, store at room temperature but use within 8 h.
- Store powder vials at 2°8° C (36°46° F). Protect from light.
Adverse Effects (≥1%)Body as a Whole:
First dose reaction (headache, fever, nausea, vomiting, myalgia), increased risk of infection
or reactivation of latent infection, chills,
pain, myalgia, flu syndrome, asthenia, hypersensitivity reactions, peripheral edema, serious infection. CNS: Headache
. GI: Nausea
. Hematologic: Thrombocytopenia
, hemolytic anemia. Musculoskeletal:
Worsening of psoriasis
Do not administer live or live-attenuated vaccines
; increased risk of immunosuppression with other immunosuppressants
50% absorbed from SC site. Peak:
Steady-state levels reached in 4 wk. Elimination:
Drug eliminated approximately 25 d after last steady-state dose.
Assessment & Drug Effects
- Monitor for S&S of infection. Withhold drug and notify physician if infection is suspected.
- Lab tests: Periodic Hgb & Hct and platelet counts.
Patient & Family Education
- Seek immediate medical attention for bleeding from gums, bruising, petechiae (numerous small red spots on skin), or S&S of
an infection (fever, abscess, sore throat with breathing difficulty, etc.), or worsening of psoriasis.
- Do not accept a live virus vaccine without consulting physician.
- Notify physician immediately if you become pregnant while taking this drug, or within 6 wk of last dose of drug.