DISULFIRAM AND WARFARIN AND OTHER ORAL ANTICOAGULANTS

The anticoagulant effects of warfarin are increased by disulfiram, and in some cases
bleeding has occurred.
It seems likely that most individuals will demonstrate this interaction. If
concurrent use is thought appropriate, the effects of warfarin should be monitored
and suitable dosage adjustments made when adding or withdrawing disulfiram.
Care should be taken when starting warfarin in patients already taking disulfiram,
and consideration should be given to using a smaller loading dose.
(33)
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