CONTRACEPTIVES AND TIZANIDINE

Hormonal contraceptives increase the levels of tizanidine by up to 4-fold: the blood pressure-lowering effect of tizanidine was increased by 12/8 mmHg.
A clinical response or adverse effect with tizanidine might occur at lower doses of tizanidine in patients taking hormonal contraceptives, therefore during dose titration individual doses should be reduced initially.
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