CONTRACEPTIVES AND TACROLIMUS

The manufacturers of tacrolimus say that during clinical use ethinylestradiol has been shown to increase tacrolimus levels, and in vitro data suggests that gestodene and norethisterone may do the same. Tacrolimus has the potential to interfere with the metabolism of hormonal contraceptives.
The manufacturers suggest that other (presumably non-hormonal) contraceptive measures should be used.
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