BUTENAFINE HYDROCHLORIDE

BUTENAFINE HYDROCHLORIDE
(bu-ten'a-feen)
Lotrimin Ultra, Mentax
Classifications: antifungal antibiotic;
Therapeutic:antifungal antibiotic

Prototype: Terbinafine
Pregnancy Category: B

Availability

1% cream

Action

Exerts antifungal action by inhibiting fungal sterol synthesis that is needed in formation of the fungal cell membrane.

Therapeutic Effect

Antifungal effectiveness against interdigital tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (jock itch).

Uses

Treatment of tinea pedis, tinea corporis, and tinea cruris due to Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum.

Contraindications

Hypersensitivity to butenafine; ophthalmic or vaginal administration.

Cautious Use

Hypersensitivity to naftifine or tolnaftate; pregnancy (category B); lactation. Safety and efficacy in children <12 y are not established.

Route & Dosage

Tinea Pedis
Adult/Child (>12 y): Topical Apply to affected area and surrounding skin b.i.d. times 7 d or q.d. times 4 wk

Tinea Corporis, Tinea Cruris
Adult/Child (>12 y): Topical Apply to affected area and surrounding skin once daily

Administration

Topical
  • Apply sufficient cream to cover affected skin and surrounding areas.
  • Do not use occlusive dressing unless specifically directed to do so.
  • Store at 5°–30° C (41°–86° F).

Adverse Effects (≥1%)

Skin: Burning/stinging at application site, contact dermatitis, erythema, irritation, itching.

Nursing Implications

Assessment & Drug Effects

  • Note: 2–4 wk of therapy are usually required for effective treatment.

Patient & Family Education

  • Discontinue medication and notify physician if irritation or sensitivity develops.
  • Avoid contact with mucous membranes.
  • Wash hands thoroughly before and after application of cream.

Common adverse effects in italic, life-threatening effects underlined; generic names in bold; classifications in SMALL CAPS; Canadian drug name; Prototype drug

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