BACLOFEN AND NSAIDS

An isolated report describes baclofen toxicity (confusion, disorientation, bradycardia, blurred vision, hypotension and hypothermia) in a patient who took ibuprofen. It appeared that the toxicity was caused by ibuprofen-induced acute renal impairment leading to baclofen accumulation.
The general importance of this interaction is likely to be very small. There appears to be no information about baclofen and other NSAIDs, and little reason for avoiding concurrent use.
(653)
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