Ciclosporin serum levels can be increased by
amiodarone and nephrotoxicity has occurred as a result. Increased
amiodarone levels and
pulmonary toxicity have been reported in patients also given
ciclosporin.
Ciclosporin levels and/or effects (e.g. on
renal function) should be monitored as a matter of routine, but it may be prudent to increase monitoring if
amiodarone is started or stopped. Adjust the dose of
ciclosporin as necessary. The significance of the increase in
amiodarone levels and the occurrence of
pulmonary toxicity is unclear but bear these reports in mind in case of unexpected effects.