ALCOHOL AND CICLOSPORIN (CYCLOSPORINE)

An isolated report describes a marked increase in serum ciclosporin levels in a patient after an episode of binge drinking, but a subsequent study found that moderate single doses of alcohol in other patients had no such effect. Red wine appears to decrease ciclosporin bioavailability.
It seems that alcohol in moderation will not affect ciclosporin levels, although greater care should be taken with red wine. However, note that the study with red wine was in patients taking the old Sandimmun preparation orally, which is known to have greater fluctuations in bioavailability than the Neoral preparation.
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